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Summary of the impact of microglial lipid droplet (LD) accumulation in AD.

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Hao Huang

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Description: Compared to normal controls and APOE3/3 AD patients, ACSL1+ microglia identified in APOE4/4 AD patients are enriched with triglyceride LDs, which are distributed around the core or the periphery of Aβ plaques. These cells exhibit lysosomal accumulation and reduced phagocytosis.

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Compared to normal controls and APOE3/3 AD patients, ACSL1+ microglia identified in APOE4/4 AD patients are enriched with triglyceride LDs, which are distributed around the core or the periphery of Aβ plaques. These cells exhibit lysosomal accumulation and reduced phagocytosis.

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