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Summary of Vitamin D Molecular Genetics at 17q12-21.1
Description
This template maps genetic interactions at the 17q12-21.1 and 21.2 loci, showing how Vitamin D and CTCF bind regulatory sites near IKZF3, ORMDL3, ZPBP2, and sphingolipid, with several labeled SNPs including rs12936231 and rs4065275 affecting these interactions. It traces how IKZF3 suppresses IL2 and enhances STAT5A/B and STAT3, linking the pathway to immune system development and to asthma, autoimmune disease, and allergy.
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