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Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction
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Description
Sympathetic innervation in skeletal muscle impacts vasomotor activity and muscle physiology, including muscle force production and synaptic vesicle release synchronization. Norepinephrine release affects protein turnover, particularly nicotinic acetylcholine receptors, possibly through downregulation of proteolytic systems. This regulation may involve adrenoceptor-mediated modulation of cAMP/PKA and HDAC4/myogenin axes. Additionally, sympathetic innervation enhances PGC1alpha signaling.
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