BioRender Template

T-cell signaling

Created by

Johanna Bartmuß

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Description:

This template shows T-cell receptor signaling at the immunological synapse, starting from TCR/CD3, CD4, CD28, and integrin engagement with an antigen-presenting cell and proceeding through ZAP70, LAT, PLCgamma1, and PI3K signaling. It traces downstream branches through calcium/calcineurin, PKC-theta, and Ras/Raf/MEK/ERK pathways to NFAT, NF-kB, and AP1 transcription factors, as well as Rac1/Cdc42-driven actin polymerization for lamellipodium formation.

Updated

August 2026

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