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Testosterone Blocks Apoptosis in the Sexually Dimorphic Nucleus
Creator
s
Description
The sexually dimorphic nucleus (SDN) of the rat is larger in males than in females. This is believed to be because testosterone in the male is converted to estradiol by aromatase in the cytoplasm of the SDN neurons; the estradiol binds to an estrogen receptor which alters gene expression so that apoptosis is blocked. In females, with low testosterone levels and little cytoplasmic aromatase, apoptosis proceeds and the SDN becomes smaller.
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