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BioRender Template
The cGAS-STING Signaling Pathway
Creator
s
Description
cGAS is activated upon binding and dimerization of dsDNA in the cytoplasm or in the nucleus. This leads to the production of cGAMP which binds to STING on the ER Inducing activation TBK1 and IRF3 leading to transcription and secretion of Type 1 Interferon cytokines.
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