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BioRender Template
The Propagation of Immunothrombosis by Leukocytes and Platelets
Creator
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Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
During inflammation, TNFα induces the exocytosis of Weibel Palade bodies (WPB) from endothelial cells, releasing P-selectin. P-selectin recruits leukocytes such as neutrophils and monocytes via P-selectin glycoprotein ligand-1 (PSGL-1). Neutrophils release neutrophil extracellular traps (NET), which capture pathogens, promote thrombus formation, and activate platelets. The activated platelets can further activate leukocytes and recognize pathogens. Tissue factor (TF) from the surface of monocytes and its microvesicles also promote thrombus formation by initiating fibrin formation and red blood cell (RBC) recruitment. The resulting thrombus in turn facilitates pathogen capture.
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