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BioRender Template
The Role of ILC2s in Asthma Pathogenesis
Creator
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Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Allergens, viruses or helminths can provoke the release of alarmins from the damaged epithelium. These stimulate the GATA3+/RORa+ ILC2s to express type 2 cytokines. Interleukins-4, -5 and -13 can cause IgE increase from plasma cells, eosinophil expansion, and airway hyper-responsiveness, respectively. Alternatively, through an unknown mechanism, alarmins can mildly stimulate ILC2s to secrete amphiregulin in order to repair the damaged epithelial cells.
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