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The Role of Tumour-associated Macrophages in Supporting Tumourigenesis

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Rosa Martins
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Description: A schematic diagram summarising the diverse roles tumour-associated macrophages (TAMs) can have within the tumour microenvironment to promote malignant tumour development. By secreting factors into the TME and expressing surface molecules that lead to the recruitment of Tregs and inhibition of CD8+ T cells, TAMs can mediate immunosuppression. In addition, TAMs participate in the metastatic spread, angiogenesis/lymphangiogenesis, and drug resistance of cancer cells.

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A schematic diagram summarising the diverse roles tumour-associated macrophages (TAMs) can have within the tumour microenvironment to promote malignant tumour development. By secreting factors into the TME and expressing surface molecules that lead to the recruitment of Tregs and inhibition of CD8+ T cells, TAMs can mediate immunosuppression. In addition, TAMs participate in the metastatic spread, angiogenesis/lymphangiogenesis, and drug resistance of cancer cells.

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