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The schematic diagram shows the potential role and mechanisms of CCL2 in NMO-IgG-induced damage.

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Mengyuan Yao

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Description: The binding of NMO-IgG to AQP4 on the cytomembrane of astrocytes activated various intracellular inflammatory signaling pathways.CCL2-derived peripheral CCR2+ monocytes penetrated the brain or attracted microglia/macrophages migrated toward the lesion focus close to astrocytes. The interaction of CCR2+ cells with injured astrocytes could further stimulate the release of inflammatory cytokines, forming a positive feedback cascade loop leading to more serious damage to astrocytes.

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What does the The schematic diagram shows the potential role and mechanisms of CCL2 in NMO-IgG-induced damage. template show?

The binding of NMO-IgG to AQP4 on the cytomembrane of astrocytes activated various intracellular inflammatory signaling pathways.CCL2-derived peripheral CCR2+ monocytes penetrated the brain or attracted microglia/macrophages migrated toward the lesion focus close to astrocytes. The interaction of CCR2+ cells with injured astrocytes could further stimulate the release of inflammatory cytokines, forming a positive feedback cascade loop leading to more serious damage to astrocytes.

Is the The schematic diagram shows the potential role and mechanisms of CCL2 in NMO-IgG-induced damage. template free to use?

Yes, you can customize this template with a free BioRender account (no credit card required). Paid plans unlock additional export formats, higher-resolution downloads, and publication permissions.

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Unlock publication permissions with a paid plan, and include 'Created with BioRender.com' in your figure legend, or cite BioRender directly per your journal's guidelines.

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