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The specific mechanism of LRG promoting fibrosis and pathological angiogenesis

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Luyao Ma

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Description: LRG signaling pathways. Both pathways depicted in the figure are completed by LRG through the regulation of TGF-β signaling. During pathological angiogenesis (right), LRG binds to ENG, leading to ECs degeneration and reduced pericyte coverage through the ALK-1-Smad/1/5/8 pathway, converting normal vessels to dysfunctional ones. During promoting fibrosis (left), LRG promotes fibroblast differentiation into myofibroblasts in an ENG-independent manner through the ALK-5-Smad2/3-CTGF pathway.

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LRG signaling pathways. Both pathways depicted in the figure are completed by LRG through the regulation of TGF-β signaling. During pathological angiogenesis (right), LRG binds to ENG, leading to ECs degeneration and reduced pericyte coverage through the ALK-1-Smad/1/5/8 pathway, converting normal vessels to dysfunctional ones. During promoting fibrosis (left), LRG promotes fibroblast differentiation into myofibroblasts in an ENG-independent manner through the ALK-5-Smad2/3-CTGF pathway.

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