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BioRender Template
Therapeutic Strategies Targeting EMT and Plasticity-Promoting Factors
Creator
s
Description
Epithelial cells maintain integrity through cell-cell adhesion structures anchored to cortical actin and cytokeratin, distributing mechanical stress. Lamin reinforces the nucleus. Hybrid E/M cells co-express cytokeratin and vimentin, have less cortical actin, form stress fibers, and show reduced lamin for flexibility. Mesenchymal carcinoma cells express vimentin, form stress fibers, and have minimal lamin. Adapted from Fig. 5, Proactive and reactive roles of TGF-β in cancer
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