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Thiram induces myocardial oxidative damage and apoptosis via interfering their cardiac metabolism
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Description
Thiram could cause cardiotoxicity by interfering with taurine and hypotaurine metabolism , pyrimidine metabolism, and glycerolipid metabolism, which further induce oxidative stress via triggering Nrf2 signal pathway. This study may provide new evidence for the molecular mechanism of cardiotoxicity caused by thiram and resonate the alarm for animals and workers who have been exposed to thiram for a long time.
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