TLR Signaling Pathway
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This template shows toll-like receptor signaling from surface receptors TLR1, TLR2, TLR4, TLR5, and TLR6 and endosomal receptors TLR3, TLR7, and TLR9, converging on the MyD88 and TRIF adaptor pathways. These pathways activate NF-kB, driving expression of inflammatory cytokines and chemokines, and IRFs, driving expression and secretion of type I interferons.
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This template shows toll-like receptor signaling from surface receptors TLR1, TLR2, TLR4, TLR5, and TLR6 and endosomal receptors TLR3, TLR7, and TLR9, converging on the MyD88 and TRIF adaptor pathways. These pathways activate NF-kB, driving expression of inflammatory cytokines and chemokines, and IRFs, driving expression and secretion of type I interferons.