TNF Pathway
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Description:
This template shows TNF-alpha signaling through TNFR1 and TNFR2, where TNFR1 activates TRADD and FADD leading to caspase 8 and caspase 3 mediated apoptosis, while both receptors converge on TRAF2 to activate MEKK, ASK1, RIP, and NIK pathways. These branches drive JNK/AP-1, MAPK/NF-kB, and IKK signaling that promote inflammation and cell survival.
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This template shows TNF-alpha signaling through TNFR1 and TNFR2, where TNFR1 activates TRADD and FADD leading to caspase 8 and caspase 3 mediated apoptosis, while both receptors converge on TRAF2 to activate MEKK, ASK1, RIP, and NIK pathways. These branches drive JNK/AP-1, MAPK/NF-kB, and IKK signaling that promote inflammation and cell survival.