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Toll like receptor and NOD-like receptor signaling pathway
Description
TLR and NLR pathways are vital for innate immunity. TLRs on cell surfaces detect PAMPs, initiating inflammatory responses via NF-κB. NLRs within cells sense DAMPs, activating inflammasomes for cytokine release and pyroptosis. Together, they defend against pathogens and maintain tissue homeostasis.
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