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Tryptophan metabolism and the kynurenine pathway
Creator
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Description
Over 90% of tryptophan is degraded to kynurenines via the kynurenine pathway (KP), while a small amount is used for serotonin or protein synthesis. KP starts with tryptophan breakdown by TDO or IDO. KYN is further metabolized into neuroprotective or neurotoxic compounds. About 60-80% of brain KYN comes from the periphery, crossing the BBB. Astrocytes produce neuroprotective KYNA and PA, while microglia generate neurotoxic 3-HK and QA.
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