Tumor Vascularization
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Description:
This template shows the stages of tumor vascularization, beginning with a hypoxic tumor releasing VEGF and other growth factors that trigger proteolytic degradation of the basement membrane by MMPs. It continues through tip cell migration, tube formation, regulation of vessel size via DLL4/Notch signaling, and pericyte recruitment via PDGF/PDGFRB to form a mature tumor vasculature.
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This template shows the stages of tumor vascularization, beginning with a hypoxic tumor releasing VEGF and other growth factors that trigger proteolytic degradation of the basement membrane by MMPs. It continues through tip cell migration, tube formation, regulation of vessel size via DLL4/Notch signaling, and pericyte recruitment via PDGF/PDGFRB to form a mature tumor vasculature.