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Unbalanced Processing of 3'UTR Activates Oncogenes in Cancer

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Roberta Cacioppo

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BioRender Team

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Description: This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. 3’Untranslated Regions (UTRs) of oncogenes with two PolyAdenylation Sites (PASs) can be alternatively cleaved and polyadenylated at proximal (p) or distal (d) PAS, resulting in a short or long isoform respectively. Protein expression from the long isoform is limited by miRNA targeting. Normally, 3’UTRs are equally processed at both PASs, resulting in balanced protein production. In cancer, 3’UTRs are preferentially processed at pPAS, causing protein overexpression underlying oncogene activation.

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This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. 3’Untranslated Regions (UTRs) of oncogenes with two PolyAdenylation Sites (PASs) can be alternatively cleaved and polyadenylated at proximal (p) or distal (d) PAS, resulting in a short or long isoform respectively. Protein expression from the long isoform is limited by miRNA targeting. Normally, 3’UTRs are equally processed at both PASs, resulting in balanced protein production. In cancer, 3’UTRs are preferentially processed at pPAS, causing protein overexpression underlying oncogene activation.

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