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Vagal afferents detect various gut-derived signals at multiple visceral sites.
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Description
Mechanical distension and mucosal stroking can be sensed across the alimentary canal, including the esophagus, stomach, and intestine. Chemical stimuli can be detected within the intestine. Post-absorptive signals, such as glucose and osmolytes, can be monitored by vagal afferents that innervate the hepatic portal area. Additionally, vagal afferents innervating the pancreas can detect 5-HT secreted by the pancreatic beta cells after glucose absorption.
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