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Vagus nerve and gut brain pathway connecting gut microbiota, vagus nerve, and prefrontal cortex
Creator
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Description
mPFC connects via NTS. Vagus afferents transmit gut signals to NTS, influencing neuroinflammation and behavior. Gut cross-section shows microbiota-host crosstalk through metabolites interacting with epithelial/immune cells. Vagotomy abolishes microbiota-driven brain effects, confirming vagal mediation. mPFC projections suggest polysynaptic gut-brain pathways that mechanisms unclear.
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