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BioRender Template
Wnt Signaling During Cardiomyocyte Differentiation
Creator
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Description
This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
Cardiomyocytes can be generated from induced pluripotent stem cells (iPSC) by mimicking embryonic cardiogenesis. The Wnt signaling pathway plays a crucial role in cardiac tissue differentiation. Wnt signaling during the first days of cell culture increases the half-life of β-catenin’s enabling its action as a transcription factor. Inhibiting this pathway at the mesoderm phase allows differentiation to continue until spontaneous beating begins. Following this, Wnt activation is resumed.
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